Sentence examples for mediates repression of from inspiring English sources

In primary erythroid progenitors, PRMT5 mediates repression of developmentally regulated β-globin locus [13].

We conclude that direct or indirect interaction of Mpt5 protein with UTR sequences mediates repression of Tec1 protein levels.

Taken together, these data suggest that NKX2.2 mediates repression of its targets by directly binding to their promoters.

It is unclear at this stage as to how NF-κB mediates repression of some target promoters and activation of others.

It can be speculated that WRI1 mediates repression of photosynthetic source functions also during seed development.

This protein binds to miRNAs which, in turn, mediates repression of their target mRNAs through post-transcriptional gene silencing.

One such modification, the trimethylation of lysine 27 on histone H3 (H3K27me3) is required for Polycomb Repressive Complex 2 (PRC2) mediated repression of a large number of genes essential for cell proliferation, cell differentiation and tumor development [ 22, 23].

MicroRNAs (miRNAs) are ∼21 24 nucleotide RNAs that mediate repression of messenger RNA (mRNA) translation through recognition of specific miRNA binding sites usually located in the 3′ non-translated region.

Together, this suggests that different site-specific factors are involved in the recruitment of distinct H2A E3 ligases to mediate repression of a specific set of genes.

Kim et al. [12] reported cross-species conservation of the Kaiso-binding site and the importance of an intact KBS for Kaiso-mediated repression of Wnt11.

However, Wnt/β-catenin could also mediate repression of Mstn indirectly, through induction of its direct target follistatin [48] that is a known negative regulator of Mstn [49].