Sentence examples for mediates silencing of from inspiring English sources
Because dSETDB1 mediates silencing of Rt1b retrotransposons in S2 cells (Figures 4 and 7).
Because the Ik1 site overlaps with an EBF binding site within the λ5 promoter and because the relative amounts of EBF and E2A have an effect on λ5 transcription, it was proposed that Ikaros mediates silencing of λ5 by competing with EBF [63].
The target sequence that effectively mediates silencing of β1-integrin expression is 5′-AATGTAACCAACCGTAGCA-3′ and of β3-integrin expression is 5′-CAAGCCTGTGTCACCATAC-3′ (sense sequences).
By recruiting PCR1 and PCR2 complexes to form heterochromatin surrounding the INK4b-ARF-INK4a locus, ANRIL mediates silencing of these tumor suppressor genes.
The results shown here indicate that Np95 interacts with Dnmt3a and Dnmt3b and mediates silencing of the CMV promoter by mechanisms that are, at least initially, independent of de novo DNA methylation.
Our results reveal a KRAS-directed pathway that mediates silencing of the entire INK4-ARF locus, is responsible for CIMP in CRCs, and is related to the pathway that silences INK4-ARF in human embryonic stem cells (hESCs).
Thus, DNA methylation-mediated silencing of miR-205 can lead to histone methylation-mediated silencing of miR-31, with EZH2 as the coordinator of the two separate events.
In the mouse, a site-specific change in methylation is sufficient to mediate silencing of the rRNA promoter [31].
Recently, a novel stress response has been described in T. brucei where RNAi mediated silencing of the signal-recognition particle (SRP) receptor results in silencing of spliced leader RNA transcription and a significant reduction in total mRNA [32].
Conversely, the loss of NF-Y binding correlates with a decrease of acetylated histones, the recruitment of HDAC1, and a repressed heterochromatic state with enrichment of histones carrying modifications known to mediate silencing of gene expression (H3K9me3, H3K27me2 and H4K20me3).
The observation that only a subset of Ring1b bound genes is derepressed following deletion of Ring1b in ES cells, suggests that additional mechanisms mediate silencing of the other Ring1b target genes.
