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This suggests that the N-terminal domain of Drosha is particularly important for Drosha-mediated transcriptional effects in human cells because it mediates interaction of Drosha with CBP80 and Pol II.
The results presented in this manuscript suggest that optineurin mediates interaction of deubiquitinase CYLD with polyubiquitinated RIP and this interaction is essential for deubiquitination of RIP by CYLD.
Second, a 10 amino acid insertion near the C-terminus mediates interaction of the mature domain with its principal substrate, hemoglobin, and with the prodomain (8).
The WD-repeat-containing domain (also found in ORCA) mediates interaction of proteins with nucleosomes/histones (Suganuma et al., 2008).
Because S231 is located in the C-terminal domain of Par-4 – which mediates interaction of Par-4 with its partners (i.e., NF- κB, PKC ζ) – we hypothesize that S231 phosphorylation may prevent these interactions.
Taken together, our results suggest that the Mrg-binding motif of Cap-H2 mediates interaction of condensin II and Mrg15 at transcriptionally active regions of chromatin to facilitate interphase chromosome compaction and unpairing.
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The Imp3 protein interacts with Mpp10p (Imp stands for "interacting with Mpp10p") and mediates interactions of Imp4p and Mpp10p with the U3 snoRNA [3], [4].
During maturation of phagosomes containing model particles a "kiss and run" fusion mechanism mediates interactions of these compartments with organelles of the endosomal pathway.
In red cells, LMO2 mediates interactions of SCL E47 with GATA1, the complex binding a composite CANNTG- N 9-GATA.
TRAF6 may mediate interaction of active TBK1/IKKi with IRF7 but not with IRF3.
Suppression of BRCA1-induced lethality in spt4Δ and spt5 yeast strains suggests that the DSIF complex may mediate interaction of BRCA1 with RNAPII.
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mediates adhesion of
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mediates stimulation of
mediates recognition of
mediates endocytosis of
mediates upregulation of
mediates proliferation of
mediates effect of
mediates acidification of
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