Sentence examples for mediate selective uptake from inspiring English sources

As noted above, these same receptors also had an impaired ability to bind HDL and mediate selective uptake of HDL-CE.

As CD36 binds HDL but is unable to mediate efficient selective uptake of HDL-CE, we hypothesized that all of the chimeric receptors would bind HDL, but only some would be unable to mediate selective uptake of HDL-COE.

In these studies, only chimeras containing the EC domain of SR-BI were able to mediate selective uptake of HDL-CE regardless of the origin of the transmembrane domains and/or cytoplasmic domains, thus establishing that the EC domain of SR-BI is the sole requirement for the selective uptake of HDL-CE.

To determine whether swapping regions of the SR-BI EC domain with a corresponding region of CD36 altered SR-BI function, wild-type and chimeric SR-BI/CD36 receptors were tested for their ability to bind HDL and mediate selective uptake of HDL-COE following transient transfection in COS-7 cells.

Because CD36 binds HDL but cannot mediate efficient selective uptake, we hypothesized that our entire panel of SR-BI/CD36 chimeras would bind HDL at levels similar to that of wild-type SR-BI, but only some chimeras would be unable to mediate selective uptake of HDL-CE.

The SCARB1 gene which encodes SRB1, a multiligand cell surface receptor, is known to mediate selective cholesterol uptake, and cholesterol efflux [34] [37], and was regarded as an attractive candidate gene.

The liver as a central organ in lipoprotein metabolism does not only mediate selective CE uptake from HDL, but also HDL endocytosis and degradation.

It was the first molecularly well-defined HDL receptor that was shown to mediate the selective uptake of HDL lipids and HDL-dependent cholesterol efflux from cells.

Surprisingly, a majority of the 16 chimeric receptors were unable to bind HDL and mediate the selective uptake of HDL-CE.

To this end, we exploited CD36, a class B scavenger receptor with a predicted topology similar to that of SR-BI that binds HDL but is unable to mediate efficient selective uptake of HDL-CE.

On the other hand, while SC 75 79) and SC 297 302) exhibited statistically significant decreases in their ability to bind HDL, their ability to mediate the selective uptake of HDL-CE was reduced, though not statistically significant.