Sentence examples for mediate selective degradation from inspiring English sources

Recently, ATG32, a mitochondrial outer membrane protein, was identified to mediate selective degradation of mitochondria in yeast cells [27], [28].

Phospho-Vpu therefore converts the nucleocytoplasmic SCFβTrCP complex into an ER ubiquitin ligase that mediates selective degradation of its CD4 client.

Small interfering RNAs mediate the selective degradation of target RNA by guiding a multicomponent RNAse.

Indeed, autophagy has been shown to mediate the selective degradation of NF-κB pathway components, including the IKK complex.

The m-AAA complexes mediate the selective degradation of non-assembled and damaged proteins (2) and exert chaperone-like activity on respiratory chain complexes (3– 5).

Macroautophagy mediates the selective degradation of proteins and non-proteinaceous cellular constituents.

The proteasome mediates controlled and selective degradation of most proteins in eukaryotic cells, and access to the proteasome is key to controlling the half-life of substrates (Goldberg, 2003; Hershko and Ciechanover, 1998).

However, signalling through the covalent modification of proteins is now accepted for a number of well-defined protein lipid interactions, and selective degradation is mediated through the proteasome [ 31, 32].

The selective degradation of cellular proteins is mediated primarily by the ubiquitin-proteasome pathway.

Although TGF-β and its signaling protein Smad6 are involved in anti-inflammatory responses through disruption of Pellino-1-mediated TLR4 signaling complex (Choi et al, 2006) and selective degradation of MyD88 (Lee et al, 2011), therapeutic interventions based on these signaling components have not been attempted for TLR4-related inflammatory diseases.

The liver as a central organ in lipoprotein metabolism does not only mediate selective CE uptake from HDL, but also HDL endocytosis and degradation.