Sentence examples for mediate folate uptake from inspiring English sources

Systems that mediate folate uptake in auxotrophs such as Lactobacillus casei and L. salivarius have been partially biochemically characterized [ 33, 34], but the corresponding genes remain unknown.

As mammalian cells are not capable of synthesizing folates de novo, these two transport systems play a critical role in mediating folate uptake for the biosynthesis of purines, pyrimidines, and certain amino acids that are necessary for cell survival and proliferation.

Folate uptake into intestinal cells is markedly increased at pH 5.5 relative to pH 7.4 [ 12, 13], suggesting that RFC1-mediated folate uptake is highly dependent on acidic extracellular pH.

Folbp1 (folate binding protein-1) mediated intracellular folate uptake is one route by which cells harvest folate cofactors.

Folate hydrolase is required for intestinal folate uptake and its polymorphism has been linked to the development of colorectal cancer [69].

Some cancer cells are known to upregulate folate receptors [ 28], which facilitates folate uptake and could fuel enhanced cell proliferation.

In the absence of RFC1, the primary route of folate uptake into cells may be the GPI-anchored folate receptor, or internalization of folate bound to the soluble form of the folate receptor via endocytosis by megalin [ 28].

There are sophisticated membrane transport systems in mammals that facilitate folate uptake [ 6– 8].

Methotrexate enters as a "blind passenger" via folate uptake mechanisms and is trapped intracellularly by polyglutamination.

The specifics of the folate uptake and release process (described in Section 2.1) support these assumptions.

Chloroplasts and vacuoles must likewise take up folates from the cytoplasm, and there is also evidence for folate uptake by intact plant cells [ 6].