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The iodide-sulfate exchanger may operate in parallel with the sodium-dependent iodide transporter to mediate iodide uptake into mammary cells.
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The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and thyroid cancer cells [ 14].
Sodium/iodide symporter is a specific iodide transporter in thyroid follicular cells, which mediates iodide uptake across the basolateral membrane (Dohan et al, 2003).
The NIS is the plasma membrane glycoprotein that mediates active iodide uptake into the thyroid follicular cells.
NIS is a membrane glycoprotein that mediates active iodide uptake in thyroid gland and some other tissues [ 48].
The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas.
The solute carrier family 5 member A5 SLcommonlymmonly referred to as the sodium/iodide symporter (NIS), is a trans-membrane glycoprotein that mediates active iodide uptake into thyroid follicular cells and thereby has a crucial role in the biosynthesis of thyroid hormones.
In vitro, AdSERE mediated human NIS expression and iodide uptake in ER+ cell lines (MCF7 and ZR75-1).
Iodide uptake by follicular thyroid cells is mediated by a transmembrane glycoprotein known as the NIS (Na+/I−-symporter), which is a thyrocyte differentiation marker that is lost in the course of thyroid carcinogenesis [ 14, 16, 17].
The rational for radioiodide treatment of thyroid cancer is based on the iodide uptake capacity of the gland, which is in large part mediated by the NIS.
Short-term inhibition of thyroid iodide uptake is not an adverse effect; it has no adverse consequences because there is rapid compensation mediated by several independent processes.
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