Sentence examples for may regulate breast from inspiring English sources

Therefore, we speculated that ZNF703 overexpression may regulate breast CSC biology through the regulation of ER and E2F1 transcriptional activities.

PIPKIγ may regulate breast cancer progression via E-cadherin-β-catenin signal pathway.

The miRNA profiles of MaSCs, BCSCs and breast cancer MCF-7 cells were compared to obtain the candidate miRNAs that may regulate breast tumorigenesis.

Repressors of BMP-6 and E-cadherin, such as δEF1, may regulate breast tumor progression and metastasis at different stages, including the initial de-differentiation of primary tumor cells and the maintenance of migratory and/or undifferentiated phenotypes.

The idea that circulating IGF-I may regulate breast cancer is persuasive, especially taking into account that IGF-I, mediated by the endocrine actions of growth hormone (GH), plays a vital role in regulating the developing mammary gland [ 11].

For example, HIF-1α may regulate breast TIC activity in a stemlike cell population expressing CD133, but HIF-1α activity may also be required by differentiated cells that may act to support TICs through paracrine signaling, perhaps via a HIF-dependent secreted growth factor such as VEGF.

CD44v4 may also regulate breast cancer cell transendothelial metastasis by functioning not only as an adhesive receptor for E-selectin, but also as a signaling transducer.

DHEAS is also positively associated with growth factors during adolescence [ 57] that may partly regulate breast development [ 58– 60].

Since HuR has been described as regulating the expression of many cancer relevant genes, we asked whether it may coordinately regulate breast cancer genes in ER+ and ER- breast cancer.

Nevertheless, these observations pose therapeutic possibilities and indicate that various chemokines may differently regulate breast cancer development, depending to a large extent on the type of leukocytes they attract.

These results suggest that, besides its established roles, BCAR3 may have additional mechanisms of action that regulate breast cancer aggressive phenotype.