Sentence examples for may regulate mammary from inspiring English sources

These results indicate that a gradient of IGF-1 signals, including both circulating and local IGF-1, may regulate mammary gland development at embryonic, postnatal, and reproductive stages, and that increased expression of IGFBP-1 decreases the efficacy of IGF-1 signals.

The failure to regulate mammary development may therefore be a result of expression of the transgene in a non-physiologically relevant cell type, as we do not currently know whether the MMTV promoter directs transgene expression in the appropriate cell type in which Id1 is physiologically expressed.

Thus a clearer understanding of the underlying endocrine and paracrine pathways that regulate mammary branching may shed light on how they contribute to cancer and how their ill effects might be overcome or entirely avoided.

Parity also causes changes in the circulating levels of hormones that regulate mammary gland development and may affect the susceptibility of the mammary gland to tumorigenesis.

Cux/CDP/CUTL1 is another MAR binding protein, known to regulate mammary specific gene transcription and breast tumorigenesis [27].

While genetic and epigenetic changes in genes that regulate mammary epithelial cell proliferation, survival, polarity and/or differentiation are probable 'initiators' of breast carcinogenesis, several lines of evidence indicate that stromal cell responses in premalignant mammary tissue may 'promote' progression to cancer and/or the metastatic capability of malignant mammary epithelial cells.

Indeed, the major mechanisms that regulate mammary morphogenesis are probably similar in all mammals.

Together, our results provide a global picture of signalling networks that may regulate key aspects of mammary organogenesis, including inductive signalling events, the initial establishment of the mammary lineage and mammary progenitor behaviour.

Taken together, these results suggest that Notch signalling may regulate ductal branching during normal mammary gland development and that unregulated Notch signalling prevents terminal differentiation of mammary epithelial cells.

Thus, elevated MAPK activity in the Cdc42-overexpressing mammary glands may regulate MEC migration and invasion to promote hyperbranching.

Jeff Rosen (Baylor College of Medicine) discussed how deletion of the transcription factor CCAAT/enhancer binding protein (C/EBP -β also resulted in a severe inhibition of lobuloalveolar development and how C/EBP -βmalsoegulate cell fate deteresultedn during mammary gland development.