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On the basis of the gene ontology analysis, we identified 83 genes that associated with apoptosis, of which 43 and 27 genes may function as positive and negative regulators, respectively, and the other 13 genes may regulate apoptosis either in both ways or in an unclear manner, according to the reported information (Supplementary Table S3).
Through its reductase activity it may regulate apoptosis, cell growth, differentiation, migration, angiogenesis, tumorigenesis, and development [17, 18].
In addition to early embryogenesis, other studies suggest that Tim may regulate apoptosis required for organ formation later in development.
Insight into how PKCδ may regulate apoptosis has been gained from studies that have investigated its subcellular localization in apoptotic cells.
For example, cellular ROS may regulate apoptosis through the mitochondrial pathway [ 10- 13].
We have therefore hypothesized that gastrin may regulate apoptosis by specifically altering the expression of individual members of the bcl-2 family of proteins.
Similar(46)
And it may regulate apoptosis-related genes such as Bcl-2 and BAX etc. [ 25, 26].
The most thoroughly characterized mammalian IAP is XIAP/BIRC4, which can inhibit caspases 9, 3 and 7, but may also regulate apoptosis through interactions with other proteins such as Smac/DIABLO, HtrA2/Omi, XAF1, TAK1, cIAP1, and cIAP2.
RASSF1A may also regulate apoptosis via the death receptor signalling pathway.
The conservation of Pacman/Xrn1 throughout eukaryotes suggests that it may also regulate apoptosis in other organisms.
Moreover, some other miRNAs, such as novel_100 (targets tetur03g00110), novel_84 (targets tetur26g00300), novel_92 (targets tetur03g00110), novel_50 (targets tetur26g00300), may also regulate apoptosis (Additional file 3: Table S3).
More suggestions(15)
may be apoptosis
may regulate axon
may stimulate apoptosis
may attenuate apoptosis
may regulate insulin
may regulate dopamine
may undergo apoptosis
may promote apoptosis
may elicit apoptosis
may increase apoptosis
may regulate memory
may induce apoptosis
may impair apoptosis
may regulate neurogenesis
may regulate bone
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