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The helix-wheel plot of β-casein 197 revealed that the hydrophobic and hydrophilic amino acids were in alternating order, indicating that β-casein 197 may kill cells by means of being combined with membranes (Fig. 1c).

One potentially important means by which DNA adducts caused by cisplatin may kill cells is by induction of programmed cell death or apoptosis [23].

SecTRAPs, in contrast, may kill cells due to their predominant prooxidant capacity (Fig. 5D), provided that there is a cellular substrate that could take the place of juglone used in our in vitro assays.

While it is conceivable that freezing-thawing may kill cells from viremic HIV-1 patients more than cells from aviremic patients or healthy individuals, we believe the postulates outlined above to represent an unlikely scenario.

Macklis et al (1992) reported that α-particles may kill cells by apoptotic mechanisms.

Next, we sought to test whether endogenous GSSG may kill cells by a 12-lipoxygenase dependent mechanism.

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Death was observed only in Jurkat cells suggesting that 10-ns EP may selectively kill cells within a heterogeneous tissue.

In contrast, mercurials inhibit enzymes as their primary mode of action, which may directly kill cells without allowing new transcription to occur, if a certain threshold is exceeded.

Studies have shown that immune response cells such as lymphokine-activated killer cells [ 27], tumor-infiltrating lymphocytes [ 28], anti-CD3 monoclonal antibody-induced killer cells [ 29], and CIK cells may kill tumor cells directly with high proliferative activity [ 30].

Cytotoxic T cells may kill infected cells in a number of ways.

Insufficient levels of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress and may damage or kill cells.

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