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Such a regime balances the pressures inside and outside of cells, which may prevent cells from injuring.
Due to its stochastic nature, attractor selection may not be as efficient as ordinary signal transduction, but it may prevent cells from dying in fluctuating environments.
Saturation of the primary signal may prevent cells from reaching the DP state (Additional file 2: Figure S1A and B).
This creates a hat trick of DNA damage: Uranium's radioactive and chemical properties both can harm DNA, and the presence of arsenic may prevent cells from repairing the damage.
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These results suggest that rapa may prevent cell death through regulating mitochondrial functions.
Although the chronic inhibition of PARP activity is likely to be harmful to the cell, it has been proposed that its transient inhibition after IR injury may prevent cell death [15].
Several NRF2 downstream phase I and II metabolizing enzymes including GSTs (GSTM3, GSTM4, etc)., NQO1, Aflatoxin B 1-aldehyde reductases (AKR7A3), epoxide hydrolase 1, microsomal (xenobiotic) (EPHX1) and UGT1A6 were significantly induced by most of the compounds and may prevent cell damage due to oxidative stress.
Therefore, they may prevent cell oxidation [ 50].
Reduced p27 levels, therefore, may prevent cell death occurring by this mechanism.
Since p53 is a protein with strong anti-proliferative and pro-apoptotic activities [ 21], we speculated that inhibition of GSK-3 may prevent cell proliferation and induce cell death in cells with wild type p53.
These results indicate that silencing cyclin D1 may prevent cell proliferation and indicate that inhibition of cyclin D1 significantly decreased the colony formation potential of cells, which correlates with the formation of cancer in nude mouse [ 19].
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