Sentence examples for may predispose cells from inspiring English sources

Finally, we found that induction of mmp-3 and mmp-10 gene expression by hypomethylation was cell-specific, suggesting that epigenetic changes may predispose cells to express stromelysin genes.

In order to test the hypothesis that mitochondrial responses are initiated by GNPs and may predispose cells to radiosensitisation, it was important to confirm that these responses were not altered with the addition of irradiation.

Modulation of BRCA1 activity is important since any deficiency in BRCA1 activity may predispose cells to enter tumorigenesis.

The miR-24-TS-SNP 829C→T occurs at a 14.2% allelic frequency in the Japanese population, and may predispose cells for cellular transformation following other events in a cell.

Increased intracellular oxidative stress may predispose cells including lymphocytes to membrane destabilization (e.g. lysosomal and mitochondrial) and subsequent apoptosis.

Alterations that promote or enable a shift in mitochondrial metabolism toward aerobic glycolysis may predispose cells to a carcinogenic-type phenotype (Vander Heiden et al. 2009).

In order to investigate whether I3C induces apoptosis in colon cells, and to address the possibility that the combination treatment of I3C plus putrescine may predispose SW480 cells to apoptosis, we compared levels of live, apoptotic and necrotic cells, determined by measurement of phosphatidylserine externalisation after treatment with I3C alone, I3C plus putrescine, or DFMO.

These results may also be quite relevant to oncogenesis; an age-related loss of p53 may predispose these cells to oncogenic transformation, perhaps generating cancer stem cells [ 67].

However, in cancer patients, normal colonic cells with high levels of 8- oxo-dG did not undergo cell death and it is possible that the mutator phenotype (Loeb et al, 2003) may predispose these cells to further accumulation of mutations and genomic instability.

Moreover, despite some controversies, ageing may predispose related cells to apoptosis by enhancing mitochondrial dysfunction40, 41.

We hypothesized that a disorganized tissue architecture may predispose tendon cells to degenerative extracellular matrix remodeling pathways, particularly within a pro-inflammatory niche.