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These measurements may influence systemic and intracellular NO levels in patients with sepsis and may contribute to the septic phenotype of microcirculatory and immunological collapse during sepsis.
Ambient particles with various sizes/constituents may influence systemic biomarkers differently.
Because these biologic responses may influence systemic hemodynamics, we investigated the effect of air pollution on blood pressure (BP).
Yet body composition and fat distribution may influence systemic hemodynamics - both systemic blood pressure and total blood volume [ 25].
Moreover, conditioned medium from macrophages exposed to DEP (NIST 2975) stimulated primary human endothelial cells (HUVEC) to release cytokines and chemokines through a TNF- α dependent mechanism, indicating that pulmonary inflammatory markers may influence systemic cells [ 52].
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Because periodontal A. actinomycetemcomitans infection is generally a local burden, it may not influence systemic inflammatory reaction until periodontitis becomes more advanced.
The permeation of isolated parabens was also evaluated and the permeation characteristics, obtained by the Moser model, confirmed that lipophilicity and molecular weight may influence the systemic absorption of these compounds.
Thus, several co-morbidities may influence the systemic levels of ELN-441.
Polymorphic variants of the genes coding for these enzymes and transporters have been identified, which may influence the systemic pharmacology of the two drugs.
The genetic variations of KDR may influence its systemic production and its effects on vascular endothelial cells in cancer patients, consequently causing individual differences in the responses of patients treated with therapies targeting KDR.
Variants in the ABO gene have been suggested to be linked to serum inflammation markers, such as tumor necrosis factor-α (TNF-α) [20], soluble intercellular adhesion molecule 1 (sICAM-1), and liver-derived alkaline phosphatase (ALP) [21], suggesting that ABO blood type may influence the systemic inflammatory response.
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