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Local low-dose release of cytokines, obtainable by gene transfer, may overcome systemic toxicity without impairing immune recognition of malignant cells by the immune system.
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Like any good anthropologist, she knows that "[i]ndividual efforts alone cannot overcome systemic forces.
The students' role, while important, should not focus on being change agents of systemic inequality (that should be left to the adults), but rather beacons of light who consistently overcome systemic inequality.
However the drawback is the accompanying systemic toxicity, which targeted treatments may overcome.
Large head metal-on-metal total hip arthroplasty may overcome polyethylene wear induced prosthetic failure, but can increase systemic cobalt and chromium ion concentrations.
Thus, intra-articular administration of immunotoxin may overcome several challenges, including non-specific cytotoxicity and immunogenicity resulting from systemic usage of the immunotoxin.
Impaired proliferation reduces the HSC pool, but high levels of local and systemic pro-inflammatory and pro-proliferative factors at the acute arthritis stage may overcome this mechanism and may lead to exhaustion of precursor pools in chronic conditions.
"But, in the long term, technology may overcome these problems.
Larger multicenter studies may overcome this limitation.
New technologies may overcome these drawbacks.
Hollywood may overcome its race problem in the United States.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com