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For instance, fetuin-A may attenuate systemic HMGB1 accumulation indirectly by facilitating macrophage-mediated phagocytotic elimination of apoptotic cells [54].
Intriguingly, ghrelin may attenuate systemic accumulation of pro-inflammatory cytokines partly via the vagus nerve (Ref. 121), suggesting that pharmacological stimulation of the vagus nerve may be an effective therapy for experimental sepsis.
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Synthetic oligodeoxynucleotides that inhibit the activity of these intracellular TLRs attenuate systemic lupus erythematosus in mouse models and may be of therapeutic benefit in human systemic lupus erythematosus.
Stimulation of the vagus nerve can rapidly attenuate systemic inflammatory responses through inhibiting the activation of macrophages and endothelial cells.
Central-acting α2-agonists attenuate systemic inflammation and improve survival in experimental sepsis.
In addition, the combination of both agents could attenuate systemic toxicity in animals.
Our results indicated that the C. butyricum combined with B. infantis could attenuate systemic inflammation in the AAD mice.
Sesamol might attenuate systemic inflammation and oxidative stress by inhibiting proinflammatory cytokine and reactive oxygen species generation in septic rats.
Currently, the intricate mechanisms by which various agents attenuate systemic HMGB1 release and protect against experimental sepsis remain poorly understood.
Finally, AChE inhibitors may attenuate the negative effect of the systemic inflammatory responses through direct or indirect mechanisms.
Piceatannol may attenuate tumor growth in a number of systemic malignancies besides hepatocellular carcinomas.
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