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This microbiome structure may enhance systemic and anti-tumour immune response via increased antigen presentation and improved effector T cell function.
Translocation of bacteria may lead to infections, and translocation of endotoxins may enhance systemic inflammation [ 41- 44].
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The larger particles (i.e. PM2.5) may result in inflammatory reactions in the small and upper airways alike, and both types of pollution may independently enhance systemic inflammation [38].
The increase in muscle glycogen and decrease in liver triglycerides experienced by the combination group suggest the salutary effects of GW501516 and PF-879 on glucose transport and fatty acid oxidation are synergistic and may further enhance systemic metabolism.
Thus, COPD related adipose tissue dysfunction may further enhance systemic inflammation and IR.
The pulmonary inflammatory response induced by UFP may trigger or enhance systemic effects including those of the cardiovascular system (Donaldson et al. 2001; Oberdörster 2001).
Its presence in the systemic circulation may enhance the systemic inflammatory response in CF, as previously seen in a murine model [ 19].
The present study suggests that mechanical ventilation may enhance the systemic inflammatory response to low levels of circulating endotoxin, even at tidal volumes that do not result in overt lung injury.
Consequently, any beneficial effects of HAM1101 may have been caused by ADM binding per se or due to this reduction in catecholamine requirements: noradrenaline may exert cardio- and hepatotoxic effects, enhance systemic inflammation and promote oxidative stress, and impair mitochondrial respiration.
There is no evidence that carmustine implants enhance systemic toxicity.
Mechanical ventilation not only may enhance the local and systemic dissemination, and perhaps growth of pathogenic bacteria, but it may also increase susceptibility to development of systemic bacteremia.
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