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These medications are systemically absorbed and may have systemic adverse effects such as cataracts and fractures [ 1, 2].
There is some evidence that UVR contributed to regulation of the hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system and that they may have systemic effects.
"High levels of foreign currency lending may have systemic consequences for the countries concerned as well as potential for cross-border contagion," the European Systemic Risk Board said in October.
Yet it is becoming clear that both ozone and temperature may have systemic and cardiac effects.
11 12 However, high-dose ICS may have systemic effects such as reduction in height velocity 6– 8 13 and adrenal insufficiency.
Senescent cells have been identified at sites of pathology in multiple diseases and disabilities or may have systemic effects that predispose to others (Tchkonia et al., 2013; Kirkland & Tchkonia, 2014).
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Such local effect may, however, have systemic consequences when a given antigen is expressed only in one particular lymph node in which stromal cell-mediated presentation may become defective, resulting in the failure to generate antigen-specific Treg maintenance.
One implication of quantifying baseline rates of cardiovascular events in DME is the advent of agents that locally suppress vascular endothelial growth factors (VEGF) in the retina but that may also have systemic effects.
The vast majority of patients with LMGC may in fact have systemic disease.
However, since budesonide given orally is largely degraded by the liver before it enters the systemic circulation, this therapy may have minimized systemic effects on tumor response.
However, given the possibility that SPA-induced ARDS may have a systemic component (as suggested by mild hypotension in two of the SPA-injured animals), further delineation of the systemic effects of SPA-associated ARDS should occur first.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com