Sentence examples for may indirectly modulate from inspiring English sources

Although it is tempting to speculate that IL-17 may indirectly modulate p53 expression through synoviolin expression we were unable to confirm this hypothesis at least at timepoints up to 24 h of IL-17 treatment (data not shown).

These additional mutations can be embedded in the same pathways and cellular processes as the gene conferring drug resistance or more changes in the same gene and may indirectly modulate the response level to the selecting drug.

Alternatively, Lola may indirectly modulate GluR levels by regulating the transcription and/or activity of other molecules.

Further investigation of the upstream molecules that may indirectly modulate COX-2 expression via both miRNAs in the future is of interest.

Moreover, maspin may indirectly modulate the pro-apoptotic protein BAX (Bcl-2-associated X protein) [ 30], increase expression of the antiangiogenic thrombospondin and affect the expression of E2F1 [ 49, 50].

Several studies have suggested that phosphorylation of ADAM cytoplasmic tails may (directly or indirectly) modulate the ability of ADAMs to cleave physiological substrates [16], [17], [19], [33].

More precisely, a polymorphism affecting the activity of COMT may directly or indirectly modulate the amount of estradiol available to be bound by membrane-bound or intracellular estrogen receptors, whereas a polymorphism potentially modulating the amount of ESR1 transcript may further affect the availability of these receptors.

However, TSG101 may directly or indirectly modulate the transcription of MMP-9 in the nucleus, based on the following observations.

These reports indicate that the targets of aspirin and salicylates may directly or indirectly modulate the activity of transcription factors, cell signalling proteins, metabolic enzymes and mitochondrial proteins.

These data suggest, as in other tissues, that PPAR γ agonization may directly or indirectly modulate the nutritional supply of glucose and lipids for prostate metabolism and differentiation.

Corticosteroids may directly or indirectly modulate the contraction of the airway smooth muscle by suppressing the agonistic responses induced by an increase in intracellular calcium or by down-regulation linked to uncoupling receptors (M2 or M3 muscarinic, H1 histaminic receptors).