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The microtubule association by Climp63 has been proposed to regulate the mobility of the translocon and, thus, may indirectly regulate the stability of the translocating complex.
In addition, Notch signaling may indirectly regulate osteoclast differentiation in vivo by regulating the differential expression of RANKL and OPG on osteoblast lineage cells (Hilton et al., 2008; Engin et al., 2008; Zanotti and Canalis, 2010).
Given the fact that metabolic disease is associated with chronic low-grade meta-inflammation, it is possible that BAF60b may indirectly regulate energy metabolism and the development of metabolic syndrome through modulating the immune system and meta-inflammation.
SCD1 activity may indirectly regulate the content of these cell cycle proteins by modulating GSK3β, a downstream target of the Akt pathway that increases the degradation of cyclin D1 [28].
These results indicate that ACE is not a BACE1 substrate, but that BACE1 may indirectly regulate the shedding of non-substrates through the β-secretase processing of other ectodomain proteases.
It is possible that β-Arrestin 2, once it is recruited to the active CXCR4 [48], [48] may indirectly regulate the phosphorylation of β-Arrestin 1 through the downstream mediators phospho-Erk 1/2 [50], and by this mechanism modulate the recruitment of clathrin and/or the ubiquitin ligase AIP4 [51], [51].
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Consequently, Fn unfolding may also indirectly regulate the mechanosignaling of tumor-associated collagen I that ultimately contributes to tumorigenesis [ 11– 13].
Activated LXRs may also indirectly regulate E2F2 expression by tethering to another TF or by regulating the expression of another factor, which in turn affects the expression of E2F2.
Alternatively, Lola may indirectly modulate GluR levels by regulating the transcription and/or activity of other molecules.
Thus, RNA binding may directly or indirectly regulate protein turnover for epigenetic regulation.
Activated AMPK may modulate key metabolic enzymes via direct phosphorylation, may directly and indirectly regulate transcriptional programs through phosphorylation events.
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