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Arginine may improve the delivery of amino acids to muscle (Robertson et al, 1994), and thus may increase protein synthesis.

This phenomenon can be explained by the hypothesis that reducing UA may increase protein production via inhibition of mRNA degradation [ 36].

Thus, redox modulation of cellular proteins comes in "different flavors"; while moderate reversible oxidations may increase protein activity, and a more sustained ROS may induce pathological modifications through stable interactions with lipids, proteins, and DNA (40).

In an observational study using regression techniques, Macias and colleagues [ 26] showed that high-protein intakes, required to achieve nitrogen balance, may increase protein catabolism, especially if combined with high caloric intake.

Phosphorylation of α-synuclein at Ser129 is a feature of LB pathology and may promote oligomerisation, while phosphorylation at Y125 may increase protein fibrillisation of α-synuclein [ 11, 29, 54].

79 These results offer indirect evidence that reduced animal size 69 may be due to increased fat loss rather than muscle atrophy, particularly given that increased p-Akt/PKB at Ser, as seen in IP6K1 knockout mice, 33 may increase protein synthesis via mTOR activation.

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Ena et al. (1995) showed that enzymatic proteolysis may also increase protein antigenicity by exposing more antigenic sites during hydrolysis with Corolase 7092 as observed for BSA and B-IgG.

For example, overexpressing the up-regulated eglD and cwpA encoded cell wall proteins, and knocking out the genes encoding extracellular proteins competing for the secretory pathway may help to increase protein secretion in this industrially important fungus.

Under these dose and duration levels, glucocorticoid treatment appears to have no effect on mixed muscle protein synthesis or mitochondrial function in humans [45] [47] but may increase muscle protein breakdown or net amino acid release (an index of catabolism) in some [45], [47], [48] but not all [46] studies.

Collectively, these data support a model in which progestogen activity in breast tissue may increase RANKL protein expression either directly, or indirectly, via PRLR/STAT5 signaling, whereas OPG protein expression may be decreased via EGFR signaling.

These shared characteristics led us to hypothesize that ELP fusions may increase heterologous protein yield in a manner analogous to prolamin seed storage proteins.

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