Together, these findings demonstrate that the function of JmjC domain-containing proteins may extend far beyond protein demethylation, supporting a complex series of protein and nucleic acid hydroxylation reactions that provide potentially exciting new regulatory principles in biological processes (Fig 4B).
Hence, practical application of the results may extend to pathogen proteins with even high homology to host proteins.
The Golgi is decorated with coiled-coil proteins that may extend long distances to help vesicles find their targets.
As briefly demonstrated with TrxA (see Fig. 1c), we are optimistic that the SecYEG-mediated folding quality control may extend to at least some other protein targets.
Integration of protein network data may extend the reach of the established method of analysis by considering the genes in a broader context.
In addition, Kil et al. reported circadian rhythms in (mitochondrially localized) sulfinic peroxiredoxin 3 in mouse adrenal cortex, suggesting that these protein oxidation rhythms may extend to other cellular organelles.
A similar role may extend to other constitutively active Gs-protein-coupled receptors that are upregulated by energy deficit, such as Gpr3 and Gpr64, and this effect is likely enhanced by the concomitant fall in Gi-protein coupled receptor expression.
We reasoned that PRIGs harboring one of these fluorescent proteins instead of eGFP may extend the number of issues amenable by these vectors.
How these proteins came to be in these tissues while their transcriptional levels were undetectable by RNA-seq remains unclear, but suggests Wolbachia proteins and their associated functions may extend beyond the tissue-specific localization of Wolbachia within the adult nematode.
Oto modification may extend to other Wnts, given the high degree of protein conservation in this family, and the widespread expression of oto in embryos and adults.
