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The majority of macrophages transform into foam cells by accumulating lipids in their cytoplasm, while other macrophages may have vascular protective and repair properties.

So the increased level of S1P occurring in diabetic HDL3 may have vascular protective effects.

The potential association between the improvement in endothelial dysfunction and the decrease in TRLs suggests that bezafibrate may have vascular protective effects.

Bezafibrate significantly decreased postprandial endothelial dysfunction, and elevations of both exogenous and endogenous triglycerides in patients with metabolic syndrome, suggesting that bezafibrate may have vascular protective effects in these patients.

He also pointed out that GLP-1(9–36) amide, the production of which is decreased by dipeptidyl peptidase-4 inhibitors, does not affect glucose metabolism but may have vascular effects and that glucose-dependent insulinotropic peptide has not yet been well studied for vascular actions.

Similar(55)

In addition, a wide range of other agents, including inhibitors of matrix metalloproteinases, anti-cytokines and general cytotoxics, may have vascular-directed effects.

There is also some suggestion that agents used for prolotherapy may themselves have vascular sclerosing properties.

Patients with PKD1 and PKD2 seem equally likely to develop intracranial aneurysms, while patients with mutations to the 5' half of PKD1 may more likely have vascular complications [ 38].

Some MHT forms, dose, combinations or route of administration may have inadequate vascular effects.

This study suggests that horses wearing double bridles and tight nosebands undergo a physiological stress response and may have compromised vascular perfusion.

In opposition, some sustained that migraine may have a vascular basis in at least some individuals and to presume that migraine is always generated from within the central nervous system "is naïve at best and unscientific at worst [99]" and "flies in the face of common sense, clinical observation and existing scientific data" [100].

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