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Silybin has been previously reported to possess anti-inflammatory properties, raising the possibility that it may reduce vascular damage in diabetic retinopathy.
Combination treatment may reduce vascular tone to a greater extent than monotherapy.
Dorzolamide added to bimatoprost may reduce vascular resistance in the OA.
Therefore, agents that target the generation of the inflammatory stimuli in the pulmonary vascular wall may reduce vascular dysfunction and attenuate the development or progression of PAH.
Adult GH deficiency (AGHD) is a distinct clinical entity, and GH replacement in AGHD can improve body composition, strength, aerobic capacity, and mood, and may reduce vascular disease risk.
Although there is preliminary evidence that vitamin K supplementation may reduce vascular calcification, especially in patients with chronic kidney disease [ 52], whether this will influence rates of LEA complicating diabetes is unknown.
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They may also reduce vascular NO by decreasing NO bioavailability, an effect attributable to NO inactivation by radicals such as O2−, which generates the noxious byproduct, peroxynitrite (ONOO−)[46].
This study shows that small dietary changes as well as increased use of statins at a population level may significantly reduce vascular mortality in the UK.
Moreover, beta agonists may reduce lung vascular permeability and increase secretion of lung surfactants [33], [34].
Pathological processes that reduce vascular NO may do so through down regulation of eNOS expression or inhibition of eNOS activity.
The latter is responsible for substantial and long-acting vasodilation, and may therefore be indicated to reduce vascular dementia.
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