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Our study was designed to test the hypothesis that long-term EECP may protect vascular endothelial cells from apoptosis by modifying apoptosis-related gene expression.
Tissue factor pathway inhibitor inhibits the initial reactions of the blood coagulation cascade and modulates cell proliferation, and may protect vascular tissue in inflammatory conditions in mammals [ 44].
These results suggest that OCN may protect vascular endothelial cell from impairment, in part, by activating the PI3K/Akt signaling pathway.
Moon et al. [ 74] suggested that angiopoietin-1 (Ang1) may protect vascular endothelial cells from iopromide-induced apoptosis through PI 3-K and mTOR/S6 kinase, postulating that the pretreatment with Ang1 could help in maintaining normal vascular endothelial cell integrity before and during systemic RCM administration.
The mechanism of this phenomenon is not fully understood, but it has been suggested that omega-3 PUFAs may protect vascular system against vasospasm and thrombosis by enhancing nitric oxide release and prostacyclin synthesis, and also by suppressing thromboxane formation [ 19].
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Naringin may also protect vascular smooth muscle cells by increasing the strength and resistance of blood vessels, which reduces the atherogenic effects [31].
RANK(L) (receptor activator of nuclear factor kappaB (ligand) may promote and osteoprotegerin (OPG) may protect against vascular calcification (table 5).
These data suggest that fasudil may protect against vascular inflammation in diabetes, in part by limiting expression of monocyte chemotactic and adhesion factors by endothelial cells.
An acute bout of exercise also is marked by a transient increase in antioxidants that may protect the vascular endothelium after a high-fat meal [ 26].
However, no genetic resources of resistance can protect vascular system from infection [ 17].
These results imply that exenatide can protect vascular endothelial cells in hyperglycemia directly.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com