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In heterolog expression systems, NPS was shown to induce mobilization of intracellular Ca2+ and synthesis of cAMP, most likely by stimulating Gq and Gs [11], [12], suggesting that NPS may enhance cellular excitability [13].

The oxidative damage produced by TNF α (Zimmerman et al, 1989) may enhance cellular damage produced by ionising radiation.

On the other hand, phosphorylated ceramide and SPH derivatives, C1P and S1P, have antiapoptotic properties; they may enhance cellular proliferation and increase angiogenesis.

In addition to its effects on motility, Src may enhance cellular invasion by regulating the expression of MMPs and tissue inhibitors of metalloproteinases [ 129].

At the same time, the method of human stem cell based three dimensional microtissues may also represent a translational therapy strategy which may enhance cellular retention, survival and integration [ 37].

Our recent study also demonstrated that long-term exposure to high glucose may enhance cellular senescence and decrease cell numbers and functional competencies of EPCs via nitric oxide (NO -related mechaNO -related

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Thus, these results suggest that, in vivo, IL-2 may enhance cellular-mediated immunity against a tumour antigen and that some MHC molecules are more efficient than others for endogenous tumour antigen presentation.

By this mechanism, the drug may also enhance cellular energy metabolism.

Subsequent hypotension, vascular leakage and microcirculatory flow impairment at reperfusion augment tissue hypoxia due to increased diffusion distance for oxygen and may thereby enhance cellular damage and organ failure [ 7, 8].

These independent but related tests confirm that the root extract may stimulate or enhance cellular migration.

Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals.

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