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Co-expression with TFs was used to identify putative promoters that may contain binding sites for TFs and could then be analyzed for TFBS enrichment [15], [16], [17].

These regions may contain binding sites for regulatory proteins such as BvgA, as shown for Ptx [ 37].

MiRNAs interact with their respective MREs in the 3'UTR of transcripts and each gene may contain binding sites for multiple miRNA.

This indicates the possibility that NRs, which can accommodate more TFBSs variations, may contain binding site sequences with lower purifying selection relative to NDRs.

If metabolites are involved in regulating mRNAs, then one also anticipates that some previously identified RNA-binding proteins may contain binding pockets for metabolites that would influence their function.

Similar(55)

They are able to regulate complex networks, due to the fact that a single microRNA can find targets in multiple mRNAs, while each mRNA may in turn contain binding sites for multiple microRNAs (Hobert, 2008).

We should point out that binding loci (peaks) refer to the larger regions produced by ChIP-based experiments, while binding motifs refer to the predicted YY1-binding sequence within each locus, so binding loci have a one-to-many relationships with binding motifs, in other words, one locus may contain multiple binding motifs.

Therefore, this discrepancy may be resulted from the possibility that the construct to be used in the experiment may contain another binding site for miR-302.

It has been estimated that eukaryotic promoters may contain 10 50 binding sites for 5 15 different transcription factors (Wray et al. 2003).

It is currently estimated that up to 30% of human genes may contain miRNAs' binding sites, which suggested a potential role of miRNAs as central regulators in the control of gene expression [ 6, 7].

In investigating the pro-myogenic properties of hESC-secreted proteins, we explored a hypothesis that key factors may contain heparin-binding domains, as many proteins known to be key mitogenic regulators of cell-fate specification and secreted by embryonic cells bind heparin or act in complex with heparin-bound proteins [ 22, 23].

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