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As it is observed in the presented crystal structures, the morpholine ring (a potential donor and acceptor of the hydrogen bonds) seems to be an attractive substituent, that may support binding to the non-specific sites of 5-HT receptors.
It is expressed by several, but not all, virulent meningococcal lineages and may support binding to both epithelial and endothelial cells [ 105].
Similar(58)
Similar to the two essential arginine residues within 7 Å of bound glutathione in the GstB homologue, YliJ, these basic residues may support a binding pocket for negatively charged species such as arsenate and monomethylarsenate.
The failure of acquiring DCC binding by larger regions of autosomal origin [ 28] may be simply understood considering that the larger the region, the closer its density of motifs will be to the autosomal average, which may be too low to support binding.
At the end of 2007, it singlehandedly blocked a Commonwealth resolution to support binding targets for industrialised nations.
In this model, AIP binding may support the opening of CARMA1 or stabilize the signal competent active conformation.
However, the impressive results yielded with EDC/NHS, the only cross-linker in this study able to additionally catalyse binding of GAGs, may support the idea that molecules other than those involved in the collagen network can also contribute to the integrative process in vitro.
Those predictions and previous biochemical studies (36) may support the hypothesis that both residues are stable binding sites for glutamate in VGLUTs.
Also binding studies or observed immunological processes may support MD results.
Previous reports have demonstrated small molecule binding to protein using a high density sensor surface and suggest that aptamer immobilization at higher densities may support a more sensitive and stable method for measuring small molecule aptamer binding.
These findings may support a new attractive model in which Tyr682 phosphorylation and its binding to adaptors may prevent Aβ accumulation and deposition in humans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com