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Thus, the surface grooves observed in the c-ring structures may provide binding sites for water molecules (or H3O+), and these putative bound water molecules may form part of a proton-wire, running from the extracellular side to the cytosol side.
Presumably, an adsorbed protein may provide binding sites that recruit and bridge ions so as to position them in a specific tridimensional configuration needed to form a mineral nucleus [101].
Similar(58)
Another possibility is that when binding to Gαq, PLCβ may provide direct binding sites on itself for Fhit which also leads to the formation of a heterotrimeric protein complex.
It is shown that calorimetry is unique in that it may provide the binding constant, the enthalpy change and, in some cases, the stoichiometry of a reaction in a single experiment.
These voids are adjacent to the base pairs and may provide a binding site.
The surface of sperm is also densely coated with carbohydrates [22], which may provide viral binding sites similar to those found on epithelial surfaces.
AKT contains a single hydrophobic motif (from residues 469 474 in AKT1), where the Ser473 residue is located, near the C-terminus [39], which may provide a binding site for GRP78.
Therefore a high local concentration of phosphorylated PPPSPXS motifs likely exists and their proximity to GSK3 via LRP6-Axin association may provide significant binding and inhibition to GSK3 in vivo even if the interaction between each phosphorylated PPPSPXS motif and GSK3 may not be particularly strong.
The TFEβ FeS domain may provide additional binding surface to the RNAP clamp.
Therefore, fluorescence-based methods as used by Lin et al. may provide correct binding affinities.
A similar observation was made by Gershenzon and colleagues [ 36] where they postulate that other core promoter motifs may provide a binding site for the basal transcription machinery in the absence of a TATA to mediate transcription.
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