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In addition, there are increasing evidence indicated that mtDNA haplogroups defined by distinct sets of mtDNA variants may confer genetic resistance against or susceptibility to certain diseases such as visual failure, diabetes and Parkinson disease (Fuku et al., 2007; Hudson et al., 2007; Khusnutdinova et al., 2008).
The study aimed to examine whether the DLG4 gene that encodes the PSD95 may confer genetic susceptibility to schizophrenia.
In addition, we will explore the FTO gene further to elucidate other potential variants that may confer genetic susceptibility to this disorder in our cohort.
The EGFR T790M mutation confers acquired resistance to kinase inhibitors in human EGFR mutant lung adenocarcinoma, is occasionally detected before treatment, and may confer genetic susceptibility to lung cancer.
In addition, we will explore the BANK1 gene further to elucidate other potential variants that may confer genetic susceptibility to this debilitating disorder in our cohort.
All of these data suggest that the chromatin structure/gene composition of this compartment of the S phase is conserved and may be important for the maintenance of cell stability and if defective may confer genetic instability.
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Instead, DISC1 disruption may confer a genetic risk at the level of endophenotypes or brain circuitry that underlies a number of major mental disorders.
For all the above-mentioned reasons, these genes alone or jointly may confer the genetic susceptibility to the HPA axis hyperactivation under stressful circumstance and cause depression and confer increased risk for the T2D and MetS phenotypes.
For children with DS, trisomy 21 may confer increased genetic susceptibility and represent the first step in a complex multistep pathway to leukemogenesis (Scholl et al, 1982; Ross, 1999).
These polymorphisms may alter the BER capacity, and in turn confer genetic predisposition to skin cancer.
Ultramafic outcrops may be conceptualized as 'edaphic islands' (Kruckeberg 1991; Rajakaruna 2004), and as such these insular features in the landscape can confer genetic isolation, which in association with locally strong climactic and edaphic stresses, may promote plant speciation and endemism (Kruckeberg 1986; Wong 2011; Rajakaruna and Boyd 2008).
Related(20)
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