Sentence examples for may confer oncogenic from inspiring English sources

The viruses are all oncogenic, and may confer oncogenic properties to DDX3.

Knockdown of mutant p53 by RNA interference causes massive apoptosis in mutant p53 breast cancer cell lines but not in wild-type p53 breast cancer cell lines, indicating that mutant p53 may confer oncogenic potential as well as loss of tumor suppressor activity [ 23].

A I638F mutation in the kinase domain of DDR2 was shown to promote the formation of cell colonies in soft agar, suggesting that the mutation may confer an oncogenic gain-of-function phenotype.

Cancer is thought to arise from a series of genetic and epigenetic changes that confer oncogenic properties on a cell and its descendents (reviewed in [1]).

Moreover, approximately half of the amino acid substitutions in mTOR listed in the cancer database similarly confer oncogenic activity.

TAp63 has an N-terminal transactivation domain with tumor suppressor activity, whereas ΔNp63 contains a truncated N-terminal domain that has been proposed to confer oncogenic properties.

Additional reports demonstrate that WT1 is expressed in hematological malignancies and solid tumors, including pancreatic ductal adenocarcinoma 11 and can confer oncogenic functions.

Hence, our results suggest that loss of YAP1 may confer aggressiveness in ER+ breast cancers independently of the established oncogenic CCND1 amplification.

Similarly, in breast cancer, oncogenic mutations in PIK3CA or low levels of PTEN expression, may confer resistance to treatment with trastuzumab, a monoclonal antibody that targets the HER2/NEU receptor (Berns et al, 2007).

A mutation that confers lethality, he explained, may confer another advantage scientists have not pinned down.

Stone monuments may confer a sense of permanence.