Sentence examples for may affect hybridization from inspiring English sources

While it can be assumed that for most of the detected cis-eQTLs indeed the probe expression is affected by genetic variation, it can also be that SNPs, mapping to regions to which the probe hybridizes, may affect hybridization efficacies and result in cis-eQTLs [ 32] that are not due to expression differences.

To investigate whether sequence variation at the probe target regions may affect hybridization and cause spurious association findings, we performed a targeted sequencing effort of 15 gene regions.

These distributions could not be accounted for by variations in GC-content [12] which may affect hybridization kinetics in ChIP-chip assays, since we observed histone modification biases both for exons and for introns (although exons generally have a higher GC-content than introns).

All probes that overlapped with SNPs from dbSNP were removed because these may affect hybridization and cause artifactual association [ 12].

The large number of probes on the chip and their high AT content (some > 80%) require critical evaluation of factors that may affect hybridization dynamics before SFP can be reliably called.

49, 70, 71 Oligo microarrays have shorter fragments of cDNA spotted on the chip, so they are less ideal for cross-species work, since few numbers of polymorphism may affect hybridization greatly.

Functionalization chemistry may also affect hybridization by increasing the distance to the glass surface and by changing the surface electrostatics and hydrophobicity, properties which are also known to influence hybridization and nonspecific target binding and, hence, background intensity.

For example, we found that the probe sequence GC-content affects the extent of cross-hybridization and may affect cross-hybridization in different ways, depending on the type of alignment between probes and transcripts.

We examined the effect of the various parameters that may affect surface hybridization.

SNPs that are within the target region of a probe may affect RNA hybridization and lead to false-positive eQTL findings [ 40, 41].

Note, however, that many rhoptry proteins are also highly polymorphic, which may in some cases affect hybridization profiles, since expression probes on the array were based on the sequence of type II strain ME49 (asterisks in tables).