A sample mixed with a smaller percentage of DNA from a different genotype (strain) may increase the hybridization background signal.
Based on our experiments with extended hybridization times, use of DAP may prove to be a useful alternative to increase array sensitivity for studies that are unable to generate enough target to hybridize or are unable to increase hybridization times because of throughput constraints.
In other cases, however, hybridization may increase evolutionary potential through elevated genetic variability and the introduction of novel genetic combinations [7].
In this instance, hybridization may increase levels of genetic and phenotypic variation to help enable the creation of new biotypes or races capable of shifting and differentially adapting to novel host plants of agricultural importance.
Testing for chromosomal aneuploidy by fluorescence in situ hybridization (FISH) may increase the yield.
RNA sample mixture complexity may increase the amount of nonspecific hybridization, magnify GC skew and boost the intensity of MM oligos at all levels.
We further hypothesized that the ongoing decline of Ch. montanus may increase heterospecific encounter probabilities and thus hybridization risk to increase with decreasing population size.
Hence, all assays were carried out conveniently at RT. Increasing the cDNA loading on the MNP can increase the affinity and amount of cDNAs available for T-DNA hybridization, and hence may increase capture efficiency.
(2004) hypothesized that hybridization between reproductively isolated populations may increase the variability in family size, if certain hybrid families contribute disproportionately to the total number of surviving offspring.
