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The percentage of the maximal workload during increasing exercise at which lactate surmounts above normal levels is called the lactate threshold.

Interestingly, a moderate inverse correlation was found between maximal workload during the maximal hand bike test and baseline levels of oxidative stress.

Mean peak oxygen consumption, peak oxygen consumption/kg body weight, oxygen consumption at the anaerobic threshold, and oxygen saturation at maximal workload during cardiopulmonary exercise testing increased significantly from baseline to 3 weeks and to 15 weeks (Table 2).

The obtained maximal workload during the steep ramp test, indicated as maximal short exercise capacity (MSEC) [ 27], the time cycled at that load and heart rate (HR) at the end of the test are recorded.

In order to achieve these benefits, patients with COPD have to train for 8 12 weeks, four times a week, at an intensity of 60 80% of maximal workload, during 20 30 minutes each session [ 31– 31].

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The aerobic exercise protocol (conducted on day 2) was based on maximal heart rate and maximal workload measured during the VO2max test conducted on day 1, and included both cycling and running.

In addition, a strong trend for improvement was shown in maximal workload achieved during the arm ergometer test (P = 0.06).

Then, the target amount of work each subject had to complete was calculated based on the following formula: Target amount of work (J) = 0.80·Wmax·2700 (seconds) Where Wmax was the maximal workload achieved during the incremental cycling test and 2700 seconds (45 minutes) was chosen to simulate a 40-kilometer time trial.

The exaggerated SBP and DBP at maximal workload but low BP during non-pedaling rest documented prior to transplant could be generated by over-compensatory mechanoreceptor activation in response to hyporesponsive chemoreceptors in the skeletal muscle beds [ 16].

As the target heart rate was maintained throughout the exercise training programme and maximal workload capacity increased, energy expenditure during each exercise session gradually increased in both groups (from 1.08 ± 0.04 MJ per session in week 1 to 1.34 ± 0.05 MJ per session by week 24).

Blood pressure normalized during unloaded pedalling but was exaggerated at maximal workload whereby it rose from 82/50 mmHg to a peak of 201/120 mmHg.

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