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These kinetics patterns were also observed in our model, during the first week of implantation BMP2 was highly expressed, while BMP7 raised its maximal expression during the second week.
In contrast, the essential two-component system WalKR was highly transcribed in the noses of individual A and D similar to the maximal expression during the post-exponential phase, suggesting a role of this regulator during colonization (Fig. 4).
The sugar kinases HXK1 and GLK1 are induced as expected as they have their maximal expression during growth on other carbon sources [ 16].
Similarly, BTG1 has been shown to negatively regulate cell proliferation and to present a maximal expression during G0/G1 phases of the cell cycle in fibroblasts [ 52].
In fact, so much of the scaffold from the first pulse remained that there was almost a 2-fold increase in maximal expression during the second pulse.
Alternatively, protein levels of these isoforms are simply building up for a more maximal expression during late development or after birth.
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For the majority of genes the change in expression compared t = 0 min was maximal for t = 60 min, whereas fewer genes showed their maximum expression during t = 30 min and t = 90 min.
Hornerin expression temporally increased during the differentiation of the gland throughout pregnancy, with maximal expression observed during lactation and involution.
CBS activity also varies with the stage of cell-growth with maximal expression occurring during cell proliferation [39].
Mus musculus LRP12/MIG13A is a novel transmembrane domain containing glycoprotein with maximal expression levels during embryonic CNS development (data not shown).
To rigorously compare the expression profiles of the major clusters, the scaled and normalized hybridization intensities were retrieved for each gene and plotted by group as a percentage of each gene's maximal expression value during the time course (because of the limited number of probe sets in the Biphasic group, these were excluded from subsequent analysis).
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