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Maximal effects were found at minimal ND content of 0.25 wt%.

Maximal effects were observed 5 10 min after 3.0 μg dose of melittin.

Time-of-addition experiments revealed that maximal effects were achieved when glycyrrhizin was continuously present starting with a 1 h pre-incubation period (Figure 1D).

The maximal effects were observed with 10 µg/ml S100A14, and evident increase in cell proliferation was noted within 48 h following 10 µg/ml S100A14 treatment (Figures 1D and E).

Maximal effects were observed with 10  μ of HP-14.

Pouch fluid analysis: maximal effects were detected at 6 hours post LPS administration.

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Maximal effects are usually achieved after 3 6 months (72) but may take even up to 1 year in individual cases (71).

EC50 and Emax⁡ (maximal effect) were reported in Table 2. Although, the potency of PSC833 in all cell lines tested was similar with the two methods, results with VRP were highly fluctuating.

In the adaptive dose-ranging, 6- or 3-month BOLD study in patients with relapsing-remitting multiple sclerosis, once-daily siponimod (BAF312) showed dose-dependent reduction of combined unique active lesion number and annualized relapse rate (ARR); near-maximal effects were observed at 2 mg.

In the CatWalk test, morphine was effective one, two and six weeks after collagenase injection and maximal effect was observed from 60 to 90 minutes.

The maximal effect was obtained at a 25-μM concentration which is similar to concentrations of PPF used clinically.

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