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Maximal concentrations were reached at 3 h post i.p. administration and declined thereafter with no detectable plasma concentrations at 24 h (Fig. 3a).

The mean maximal concentrations were similar.

Maximal concentrations were reached within approximately 15 min for all active treatments.

Most biomarkers were ubiquitously detected, and maximal concentrations were in the range known to elicit effects experimentally (e.g., > 10 μmol).

Maximal concentrations were observed in the 200-mg group (1.8 vs. 1.3 nmol/l in the placebo group; P < 0.05).

Maximal concentrations were determined on day 1 with values reaching 365  μg/mL (median 179  μg/mL).

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Similar(51)

Recovery from both compounds, even at maximal concentrations, was rapid, and no mortality out to 24 h was noted.

Although drug absorption into the bloodstream is slower and a delay of several days is possible before maximal concentrations are reached, desired outcomes can be achieved.

Antibiotics are preferentially delivered via the peritoneal route to treat peritonitis, a major complication of peritoneal dialysis (PD), so that maximal concentrations are delivered at the site of infection.

None of the remaining compounds/oils used at the maximal concentrations was able to improve significantly the inhibitory effect produced by 30  μM α-T on lipid peroxidation, in both the cell lines and all experimental conditions.

The maximal concentration was found at 12 00 AM in the third pig.

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