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Maximal effects occurred between weeks 10 and 24 of therapy.
Threshold effects were observed with 1 μM Pred, with a number of adherent platelet reduced to 21.8 ± 4 platelets/0.01 mm, while maximal effects occurred at 10 μM Pred, when adherent platelets fell to 6.8 ± 2.9 (hence > 80% reduction; P < 0.01) (Fig. 3B).
The overall ANOVA for a single dose measured in three regions at four time points was significant (F4,15 = 24.9 p < 0.0001) with a significant effect for region (F2,15 = 61.0 p < 0.0001) and an interaction of region with time point (F8,30 = 3.0, p = 0.013).. Maximal effects occurred between 1 and 7 days.
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As shown in Figure 1, the stimulatory effects of glucose on SR-A, CD36 and LOX-1 mRNA expression were dose-dependent, with the maximal effects occurring at 30 mmol/L glucose.
injection of the CCKB receptor antagonist L365,260 produced a dose-dependent (0.125 2.0 mg/kg) potentiation of the analgesia induced by 100 Hz EA, with a maximal effect occurred at 0.5 mg/kg.
Its maximal effect occurred 30 minutes after injection with a decrease of 21±3%3% in the Knee-Bend score (P <0.05, Figure 3E) and an increase of 22 ± 5 in the %TIPPI in the CatWalk test (P <0.05, Figure 3F).
Three hours' hypoxia stimulates microglial cells iInducible nitric oxide synthase (iNOS) gene expression; iNOS gene expression significantly upregulated with its maximal effect occurred at 6 h' culture (up to 23.9 folds of the control).
The pre-incubation of harpagoside can down-regulate hypoxia-induced iNOS gene expression with its maximal effect occurred at 24 h' culture (down to 0.1 folds of the control) (Fig. 4).
In this study, 3 h' hypoxia stimulates microglial cells to up-regulate their IL-1β and IL-6 genes expression, with its maximal effect occurred at 6 h' culture.
The maximal effect occurred at 1 ng/ml Dex, which, perhaps tellingly, also happens to be the minimum dose at which Dex nearly completely suppresses activated T cells on its own.
Three hours' hypoxia stimulates microglial cells to up-regulate their cyclooxygenase-2 (COX-2), interleukins (IL-1β and IL-6) genes expression, with its maximal effect occurred at 6 h' culture; while for the tumor necrosis factor (TNF-α) gene, its maximal effect was at 0 h' culture.
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