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Observations such as these led to the conclusion that Pax6 is a "master control gene" responsible for eye formation and that it has served this role at least since the last common ancestor of insects and vertebrates.
In this work, we show that B52, an SR protein splicing factor, controls the production of two alternatively spliced isoforms ey and ey (2a) of eyeless, a master control gene for eye morphogenesis.
The ey gene is a master control gene for eye morphogenesis, because the Ey isoform of the gene has the ability to induce ectopic eye structures in several imaginal discs [42], [43].
These results show for the first time that a splicing factor, namely, B52/SRp55 directs eye size through production of two alternatively spliced isoform of Eyeless a master control gene for morphogenesis.
The Pax6 gene is famous for its essential role as "master control gene" for eye development.
The finding of Pax6 as a universal master control gene for eye development has resolved this paradox.
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The extraordinary variety of animal body shapes, after all, has been found to grow out of a relatively few master control genes.
The Hox genes are the master control genes for animal embryonic development and are organized into conserved clusters.
PAX6 is widely expressed in the developing eye and is one of the master control genes in eye development.
Runx genes have been referred to as "master control genes" owing to the rate-limiting roles that they play in the developmental differentiation of specific cell lineages, and as both "oncogenes" and "tumor suppressors" in reference to the neoplastic effects associated with both gain and loss of Runx function (Cameron and Neil, 2004; Ito, 2008; Ryoo et al., 2006).
So which is the true master-control gene for the fly eye?
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