Sentence examples for master switch gene from inspiring English sources

Furthermore, the hepatic master switch gene C/EBPβ appears to be reduced during the induction of ductal cells and when overexpressed inhibits the ductal phenotype.

We found that, besides its ability to bind U1 snRNA, SNF can also bind polyuridine RNA tracts flanking the male-specific exon of the master switch gene Sex-lethal (Sxl) pre-mRNA specifically, similar to Sex-lethal protein (SXL).

Pdx1 is one such master switch gene.

In studying Drosophila sex determination, we found that HP1a plays both a repressive and activating role on the master switch gene, Sex-lethal (Sxl; [ 15]).

When the ratio is 1 (XX AA), the master switch gene, Sex lethal (Sxl), is activated and sets in motion a cascade of regulatory genes, transformer (tra), transformer-2 (trand andoublesexex (dsx), that result in female development.

Interestingly, IL1-β and TNF-α activate the CDX2 promoter with concomitant expression of intestinal markers (Kazumori et al, 2006; Wong et al, 2005), which buttresses the connection between metaplasia and inflammation and the notion that master switch gene products, such as CDX2 or C/EBPs, are regulated by cytokines and inflammatory stimuli (Tsukada et al, 2011).

Transcription factors represent "master switch" genes, which regulate expression of differentiation-related molecules with both structural and functional specificity, and, thus, mediate metaplasia.

Two such potential master switch genes, the sf-1 and wt-1 genes that are involved in the formation of a bipotential gonad, have been proposed on the basis of their early significant differential expression before the onset of the TSP in reptiles with TSD.

Taken together, dsx is not the sex determining master-switch gene but only a nexus for sexual differentiation.

In recent years, our knowledge of the conserved master-switch gene doublesex (dsx) and its function in regulating the development of dimorphic traits in insects has deepened considerably.

Doublesex has thus far been regarded as the final master-switch gene in the sex determination cascade of all studied insects.