Sentence examples for master checkpoint gene from inspiring English sources

The Ph1 locus has been defined to a cdk-like gene cluster related to Cdk2 in humans, a master checkpoint gene involved in the initiation of replication and required for early meiosis.

We found that expression of Rpn4*, while imposing no effect on DNA checkpoint activation, displays a synthetic growth defect with deletion of the MEC1 checkpoint gene and sensitizes several checkpoint mutants to DNA damage.

Ecdysone is produced in older follicles that passed the stages 8 9 and is required to progress past this master checkpoint (Buszczak et al., 1999; Carney and Bender, 2000).

p21 is a critical cell-cycle checkpoint gene, regulated tightly by p53.

Unpaired chromosomes can trigger a synapsis checkpoint independent of the DNA-damage checkpoint, which requires the activity of PCH-2, the C. elegans homologue of PCH2, a budding yeast pachytene checkpoint gene.

hRad9 is a cell cycle checkpoint gene that is up-regulated in breast cancer.

Here we report that induction of the SYK gene expression in human cells causes a significant down-regulation of evolutionarily conserved genes associated with mitosis and cell cycle progression providing unprecedented evidence that SYK is a master regulator of cell cycle regulatory checkpoint genes in human cells.

Gadd45a is one of the DNA-damage checkpoint genes that have been implicated in ATM-p53 pathway (Zhan, 2005).

Researchers suspect that problems with these checkpoints may lead to cancer, although they rarely find mutations in checkpoint genes in tumors.

In a hunt for new checkpoint players, Daniel Scolnick and Thanos Halazonetis of the Wistar Institute in Philadelphia discovered a new human gene named chfr, whose DNA sequence resembles that of other checkpoint genes.

Thus, YBP2 has a temperature-sensitive conditional synthetic-lethal interaction with spindle checkpoint genes.