Sentence examples for many pathway components from inspiring English sources

Vertebrates and Drosophila also differ in the number of genes encoding many pathway components.

The Hh pathway plays pivotal roles in the development of both vertebrate and invertebrate animals, and previous studies have shown conserved roles for many pathway components during evolution.

The pathway is most famously characterized in C aenorhabditis elegans, as mutations in many pathway components can lead to a many-fold increase in lifespan (Kenyon 2005).

Although the pathway is known to be globally activated in many tumors [ 50] here we observe – consistently both in human and dog – a down-regulation of many pathway components.

Estrogens also appear to negatively regulate TGFβ signaling in breast cancer [ 9] and there is evidence that many pathway components may be epigenetically regulated during critical transitions in malignant progression [ 10].

Since the discovery of NF-κB twenty-six yeago ago [ 5, 6], much insight has been gained into the regulation of its signaling and many pathway components have been characterized [ 7].

Advisors felt that increasing caseloads and the short-term nature of many Pathways components limited their ability to provide the long-term engagement needed for those furthest from the labour market, particularly those with more complex (often mental) health conditions.

Although many Drosophila Hippo pathway components have mammalian orthologs, and although many of these have been demonstrated to have similar functions to their fly counterparts, great care must be exercised when investigating Hippo signaling in mammalian systems as it most likely will prove to be more complex and nuanced.

While many core JAK/STAT pathway components have been discovered in Drosophila via classical genetic approaches, the identification of pathway regulators has been more challenging.

68 However, many of MAPK pathway components seem to have both pro-tumorigenic and antitumorigenic functions, depending on the context (Table 2).

This set of five genes is just one example of the many changes in known pathway components that can be constructed into mechanistic and testable hypotheses from this dataset.