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In addition, proteases play key roles in many pathophysiological conditions; for example, in collagenase-mediated diseases associated with skin, the oral cavity, amniotic membranes, the lungs, the eye, muscles and soft tissue, and the central nervous system.
Urate increases in many pathophysiological conditions, for example, in renal failure, which may develop in sepsis.
Oxidative stress has been implicated in the development of many pathophysiological conditions including diabetes.
Excessive and unregulated NO synthesis is implicated in many pathophysiological conditions, including cancer [ 43– 43].
Subversion of intracellular control mechanisms is linked to many pathophysiological conditions.
Impaired lymphatic function has been implicated in many pathophysiological conditions, including asthma, diabetes, edema, and obesity [ 1– 3].
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G protein-coupled receptors (GPCRs) are the primary targets of drugs prescribed for many human pathophysiological conditions such as hypertension, allergies, schizophrenia, asthma, and various types of cancer.
The sigma-1 receptor is a unique non-opioid, non-PCP binding site that has been implicated in many different pathophysiological conditions including psychosis, drug addiction, retinal degeneration and cancer.
Reactive oxygen species (ROS) can react with DNA, proteins and lipids and play important roles in many physiological and pathophysiological conditions, such as diabetes, neurodegenerative diseases, cancer, and aging [11].
SIRTs have been demonstrated to play important roles in many physiological and pathophysiological conditions, including metabolism, cell survival, cancer, aging and calorie restriction-mediated longevity of organisms ranging from yeasts to humans [21], [22].
MicroRNAs are post-transcriptional regulators that are involved in many physiological and pathophysiological conditions.
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many pathophysiological situations
multiple pathophysiological conditions
several pathophysiological conditions
diverse pathophysiological conditions
many pathophysiological consequences
many thyroid conditions
many pathophysiological events
many pathophysiological disorders
many medical conditions
many pathophysiological features
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many experimental conditions
many respiratory conditions
many pathological conditions
many pathophysiological insults
many pathophysiological pathways
many pathophysiological mechanisms
many pathophysiological states
many cellular conditions
many pathophysiological problems
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