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In addition to being an early step in tumor metastasis, EMT is known to be associated with many pathophysiological situations, such as formation of various tissues during embryonic development [5], and of keratinocytes during wound healing [6].
Carbon tetrachloride (CCl4) intoxication in animals is an experimental model that mimics oxidative stress in many pathophysiological situations [ 5].
Changes in mtNOS expression and activity in many pathophysiological situations may imply its significant involvement in various NO-related biological phenomena.
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Despite the fundamental contribution of neutrophil platelet interactions to many inflammatory pathophysiological situations, no reliable in vitro system was available to study precisely how platelet ligands direct neutrophil behavior at the molecular level.
In the early period after a severe burn, many pathophysiological changes take place.
Laboratory information systems (LIS) have difficulty in reporting reference ranges (RR) in different pathophysiological situations.
Exposure to environmental pollutants and drugs can result in pathophysiological situations in the body.
Sulfur amino acid deficiency occurs in certain pathophysiological situations (e.g. protein-calorie malnutrition).
By further such experiments we may advance the understanding of how this tissue may react in pathophysiological situations.
This has immense implications in drug screening, and development – which also entails much testing, and selection, in pathophysiological situations.
Melatonin (Mel) has been successfully used as a potent antioxidant against many pathophysiological states.
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