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8 But the long-term use of estrogen in the form of hormone replacement therapy triggers many pathophysiological events.
This shows that estrogen treatment has a beneficial effect on reversing skin aging signs and maintaining skin elasticity in postmenopausal women, 25 but its long-term use in the form of hormone replacement therapy triggers many pathophysiological events.
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They are related to cardiovascular diseases, neuronal functions, metabolic syndromes, and many other pathophysiological events (Poudyal et al., 2011; Baum et al., 2012; Jiao et al., 2014).
Many investigators use chondrocytes in vitro to study physiological and pathophysiological events while mimicking in vivo biological conditions.
However, we cannot rule out the possibility that DOR signals may target proinflammatory cytokines after I/R stress since many cellular and molecular mechanisms function differently at various stages of pathophysiological events.
It has been indicated that the pathway of cyclooxygenase products, such as TxB2 and PGE2, increases in many endotoxic shock models and plays an important role in a number of pathophysiological events [ 21, 27].
Only some pathophysiological events are schematized (see text for details).
Neurotrophic factors are probable mediators of these pathophysiological events.
P2Y6 receptor (P2Y6-R) is involved in various physiological and pathophysiological events.
Thus, 2D evaluation of chemosensitivity may not reflect pathophysiological events seen in patients.
Melatonin (Mel) has been successfully used as a potent antioxidant against many pathophysiological states.
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