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injected antagomirs showed a broad biodistribution and miRNA silencing in many mouse tissues in vivo.
11β-HSD1 is expressed in many mouse tissues, most notably the liver, adipose, muscle, adrenal, and pancreas.
CR attenuates aging-associated shrinkage of telomeres in many mouse tissues and reduces the incidence of tumors in mice that overexpress telomerase [ 75].
SRD directed and participated in the harvesting of the many mouse tissues required for the study and he contributed to the design of the expression detection experiments.
Duxbl mRNA can readily be detected by RT-PCR in many mouse tissues including brain, liver, lung, kidney (unpublished data and references[ 18, 24]), while protein expression has been shown in a subset of tissues[ 18, 24].
The reduction in p53 dosage that results from heterozygosity at the genetic level has been shown in many mouse tissues to result in an intermediate level of transcriptional activity, growth control and apoptosis compared with wild-type and Trp53-/ cells [ 12- 14].
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Likewise, many mouse tissue eQTLs are also sexually dimorphic [12], [13].
The yolk sac is believed to be the major source of progenitors of many mouse tissue macrophage populations, notably the microglia of the brain, based upon lineage trace studies [ 39].
Northern analysis showed that Dlk1 is expressed in many adult mouse tissues, including brain, kidney, testis, and thymus.
As Figure 10 shows, Northerns using a probe that would detect both Meg9 and Mirg demonstrate that Meg9/Mirg is widely expressed in many adult mouse tissues with the highest levels being in the brain, skin, and testis.
Low levels of Nanog were detected in many adult mouse tissues.
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