Sentence examples for many mouse mutants from inspiring English sources

The generation of many mouse mutants carrying defects in repair pathways yielded valuable models for assessing the clinical relevance of DNA repair including carcinogenesis and the identification of a link between DNA damage and premature aging.

A role for PCP in patterning the mouse blastoderm prior to ciliogenesis has not been shown, although it has been suggested that many mouse mutants lacking normal left right axis specification, may do so because they lack normal PCP signaling.

Not only have mouse models have been crucial in identifying many of these genes, but in addition many mouse mutants have recapitulated the variety of pathologies, age of onset and mode of inheritance of human deafness (Brown et al. 2008).

Summarizing, sperm head shaping and nuclear condensation are tightly regulated processes involving proper chromatin remodelling and accurate assembly of cytoskeletal (manchette) and cytoplasmic (acrosome) structures as is demonstrated by the many mouse mutants that affect this process and hence fertility (Hermo et al., 2010; Kierszenbaum et al., 2007).

Many mouse mutant studies have serious methodological problems leading to fatally flawed scientific conclusions, causing a waste of time, effort, and research resources, and leading to ethical problems because of the unnecessary use of live animals for flawed studies.

Third, the deletion mice were able to maintain their core body temperature in a 4°C environment, in contrast to many obese mouse mutants, such as ob/ob, db/db (null for leptin receptor), and stat3-/ mice, that quickly become hypothermic in the cold [24], [45].

Many of the deaf mouse mutants have defects in the sensory hair bundle, the structure that detects the sound-induced movements of the cochlear fluids and transduces these stimuli into electrical signals.

These mouse mutants phenocopy many features associated with human individuals that harbor UPD for the syntenic region of chromosome 14.

You've been working with mouse mutants for many years now.

Comparison of human deafness loci and the map positions of known deaf mouse mutants shows that many loci do not have a comparative locus in the other species (Parkinson & Brown 2002), emphasizing that a large number of genes remain to be discovered.

However, many additional phenotypes were detected in the mouse mutants suggesting additional features that might also occur in patients that have hitherto not been reported.