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Although phenotypic data for many mouse strains already exist, "we're starting fresh," Brown says.
Klra4 is closest to 130M in Chr 6, but lost in many mouse strains (Cutler and Kassner, 2008 ).
This is an important issue since this mutation has been found in many mouse strains across the world (18).
To accurately model a particular human tumor, many mouse strains generally have to be interbred in a costly and labor intensive process.
Although mouse models have proven useful for TB drug discovery, many mouse strains fail to accurately reproduce the pulmonary pathology observed in human disease.
So important is Dll4, that like VEGF, haploinsufficiency of the Dll4 gene is embryonically lethal in many mouse strains, as a result of extensive vascular defects [ 7- 9].
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So important is Dll4, that like VEGF, haploinsufficiency of the Dll4 gene is embryonically lethal in many mice strains, as a result of extensive vascular defects [ 7- 9].
Interestingly, darcin is only found at trace levels in many inbred mouse strains of the Castle lineage, including many common laboratory strains such as BALB/c [ 8].
Smithies and Evans also both quickly created rodents lacking the cystic fibrosis gene, one of many knockout mouse strains created to mimic a human illness.
For example, many inbred mouse strains have been sequenced to characterize their genomic variation (Keane et al., 2011).
Our initial investigations into the genetic predisposition of autoimmune myocarditis involved infecting many inbred mouse strains with CB3 (22 ).
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