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Many mouse studies have been performed to study the effect of dietary fat on the etiology of obesity, a major risk factor of the metabolic syndrome [1], [2], [3], [4].
The AIL approach has been applied successfully in many mouse studies (e.g., [ 16]).
The mechanisms by which gut microbiota contribute to the pathophysiology of obesity have been investigated in many mouse studies and, thanks to their results, we can now draw a clearer picture of the impact of gut microbiota on maintaining energy balance of the host.
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The relevance of IAP family proteins in vivo has been demonstrated by many mouse model studies.
Many mouse mutant studies have serious methodological problems leading to fatally flawed scientific conclusions, causing a waste of time, effort, and research resources, and leading to ethical problems because of the unnecessary use of live animals for flawed studies.
Animal models, particularly mouse models, have been crucial to our understanding of immunology and immune tolerance, as evidenced by the many mouse model studies that are highlighted in this Review.
Many other mouse studies have also since confirmed this.
Furthermore, many of the mouse studies performed to date have failed to demonstrate a virulence role for PVL, thereby provoking the question: does PVL have a mechanistic role in human infection?
Widespread and tissue-specific age-related DNA methylation changes have been reported in many mouse and human studies [ 20].
There are many mouse models available to study the mechanisms of obesity [39].
SRD directed and participated in the harvesting of the many mouse tissues required for the study and he contributed to the design of the expression detection experiments.
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