Sentence examples for major unresolved question from inspiring English sources

Therefore, a major unresolved question for the majority of SUMO substrates is exactly how SUMOylation is initiated and regulated.

A major unresolved question is the future of Dr. Donald A. Young, chief operating officer of the Health Insurance Association of America, who is seeking a senior position in the new organization.

Uncertainty about which of these biological properties is the most important for explaining their anti-atherogenic effect is a major unresolved question in the field.

It has been suggested that had Otto and Amalia borne an heir, then the King would not have been overthrown, as succession was also a major unresolved question at the time.

A major unresolved question concerns the mechanism responsible for ISG induction.

However, a major unresolved question is whether the mechanism of action involves AdipoR1 and APPL1.

Major unresolved questions concern the properties of nonequilibrium, shock-driven turbulence, stochastic properties of ignition events, and the possibility of unconfined DDT.

Here, we review structural mechanisms of ligand recognition and selectivity of GPCRs with a focus on selected examples from classes A, B, and C, and we highlight major unresolved questions for future structural studies.

One of the major unresolved questions in the field was to understand how these viral secreted proteins bind chemokines with high affinity, despite having no amino acid sequence similarity to the host chemokine receptors, which are seven-transmembrane-domain proteins that cannot be engineered as soluble proteins.

Major unresolved questions regarding vertebrate limb development concern how the numbers of skeletal elements along the proximodistal (P-D) and anteroposterior (A-P) axes are determined and how the shape of a growing limb affects skeletal element formation.

There are two major unresolved questions regarding occult metastases.